H3 Book Index:: Chapters 1-29
What had Prof. AsIan actually said to engender such skepticism?
She had described her experiments and their results, in the 25 original cases, and the 45 old people who were being treated at that time as residents of the institute. She cited some specific case histories from the original group of patients, and summarized her observations of the results of GH3 therapy in both the in-patients and 2500 oldsters who were being treated on an out-patient basis, as follows:
"Our initially cautious and limited investigations, originally restricted to twenty-five cases, have been expanded appreciably in the last two years, thanks to the innocuousness of the substance involved (novocain) and to the successes gained.
"Clinicaly we have achieved a reversal of phenomena which until now have been considered irreversible, e.g., in cerebral arteriosclerosis. Sustained improvement was achieved in cases of senile Parkinsonism, improvement in hearing, and in certain reflexes which could not be elicited prior to treatment. Also, renewed production of estrogens and of characteristics resulting from stimulating of testes and adrenal glands, retrogression of signs of senility of the skin, such as ichthyosis and senile keratosis, repigmentation of existing hair, stimulation of new hair growth, and fewer arteriosclerotic symptoms.
"Physiologically we found improvement of the central activity of the nervous system, improved cardiovascular reaction to stress on the part of old people, decreased oxygen consumption, better muscle power.
"Biochemically we found alterations in protein structure and in the ratio of albumins to globulins, increase in cholesterol (as
compared to lower than normal values prior to initiation of treatment).
"Hematologically we found fewer leucocytes, higher production of granulocytes, increase in the number of monocytes and the globulin content.
"Eutrophic action was clearly visible in cases of atrophic ulcer, stomach ulcer, dermatosclerosis, psoriasis, rashes, alopecia areata and leucoderma.
"It can be stated that novocain reduces the biological age of those treated with it below the chronological age. Novocain affects directly the cerebral cortex and its dynamics, and acts on the whole nervous system, the diencephalon centers, the spinal cord, peripheral nerves, metabolic processes, and brings about trophic changes in the entire organism. It also affects the endocrine glands. Through its vitamin-like action (due to its content of para-aminobenzoic acid) it also acts favorably on the biocatalysts, and it seems to stimulate the intestinal flora to the production of biogenic agents.
"Its trophotropic action can also be observed in arteriosclerotic processes. Its effect in mobilizing the cholesterol of the blood vessel walls may be due to its hydrotropic action, characteristic of the chlorides of para-aminobenzoic acid.
"Novocain minimizes the feeling of sickness and leads to a heightened desire and capacity for physical and mental activity. By virtue of its trophic action and its role as stimulator in most vital processes, it may be considered a useful prophylactic and therapeutic substance in the fight against old age."
Why did the doctors in Karlsruhe find these words
impossible to believe? First, undoubtedly, because the
word "rejuvenation" brought back memories of the Brown-Sequard fiasco, and they had not listened attentively enough to realize that Prof. Aslan was by no means claiming that her therapy would make old people young again. Yet even her modest claim". . . a useful prophylactic and therapeutic substance in the fight against old age. . ." seemed too good to be true.
Her suggestion that novocain be termed "H3" may also have led some inattentive listeners to believe she claimed to have discovered a new substance. And, finally, there was still no scientifically unassailable proof
that even if all Prof. AsIan reported was true, novocain deserved the credit. We will discuss in a later chapter the type of rigidly controlled experiments which will
be necessary to prove finally or disprove the efficacy of novocain injections in old age.
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H3 Book Index:: Chapters 1-29
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